何泓良,教授,博士生导师,东南大学青年首席教授,国家高层次人才青年项目获得者。主要从事纳米药物设计工作,长期致力于利用纳米技术围绕血管疾病(如动脉粥样硬化等)构建精准治疗新技术和新方法。近年来主持承担国家自然科学青年基金、南京市留学人员科技创新项目;作为课题骨干参与国家重点研发计划。目前担任《Nano Research》、《Nano Materials Science》、《Asian Journal of Pharmaceutical Sciences》、《Acta Materia Medica》、《VIEW》等期刊青年编委。
研究成果:
在 Science Advances, ACS Nano, Accounts of Chemical Research, Biomaterials, Nano Today, Nano Letters, Journal of Controlled Release等发表论文40余篇;曾获美国心脏协会博士后研究基金资助,获美国心脏协会Young Investigator Travel Award。
科研项目:
国家高层次青年人才项目,2023-2025年(项目负责人)
国家自然科学基金青年基金项目,2023-2025年(项目负责人)
国家重点研发计划,2022YFF0710804,2023 – 2025年 (课题骨干,参与)
招生信息:
硕士研究生1-3人/年;博士研究生1-2人/年。专业背景包括但不限于生物医学工程,药学、高分子材料、化学等,欢迎各位感兴趣的同学联系(drhe518@seu.edu.cn)!
近年部分代表性论文:
1 H He, Q Han, S Wang, M Long, M Zhang, Y Li, Y Zhang*, N Gu*. Design of a Multifunctional Nanozyme for Resolving the Proinflammatory Plaque Microenvironment and Attenuating Atherosclerosis. ACS Nano 2023, 8;17(15):14555-14571.
2. D Liu, H He, (Equal Contribution) F Kong, Y Cao, F Zang, M Ma*, N Gu*, Y Zhang*, A versatile metal–organic nanoplatform in combination with CXCR4 antagonist and PD-L1 inhibitor for multimodal synergistic cancer therapy and MRI-guided tumor imaging, Nano Today 2022, 47, 101689
3. H He, TA Halseth (Equal Contribution), L Mei, C Shen, L Liu*, A Schwendeman*. Nanodisc delivery of liver X receptor agonist for the treatment of diabetic nephropathy. Journal of Controlled Release 2022, 348, 1016-1027.
4. H He, R Adili (Equal Contribution), L Liu (Equal Contribution), K Hong, M Holinstat, A Schwendeman*. Synthetic high-density lipoproteins loaded with antiplatelet agent for efficiently inhibiting thrombosis in mice. Science Advances 2020 Dec 4;6(49): eabd0130.
5. H He, J Wang, P Yannie, WJ Korzun, H Yang*, S Ghosh*. Nanoparticle-based “Two-pronged” approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux. Biomaterials 2020:120333.
6. H He, L Liu, EE Morin, M Liu, A Schwendeman*. Survey of clinical translation of cancer nanomedicines-lessons learned from successes and failures. Accounts of Chemical Research 2019, 52, 9, 2445-2461. Special issue “Nanomedicine and Beyond”.
7. H He, C Guo, J Wang, WJ Korzun, XY Wang, S Ghosh*, H Yang*. Leutusome: A biomimetic nanoplatform integrating plasma membrane components of leukocytes and tumor cells for remarkably enhanced solid tumor homing. Nano Letters 2018, 18 (10), 6164-6174.